dosage regimen meaning in english

An example is, "pre-op" meaning |pre-operation| (patient who is being prepared for surgery). If your doctor doesn’t provide a recommendation, it’s best to start with a smaller dosage and gradually increase it. A shortening of the PR interval was also recorded in those treated with 10 mcg/kg granisetron. Patients were randomized to 10 or 40 mcg/kg of granisetron before each cycle of chemotherapy. Define Modern medicine. Addiction is when the body or mind badly wants or needs something in order to work right. a Each strength of suspension of AUGMENTIN is available as a chewable tablet for use by older children.. b Duration of therapy studied and recommended for acute otitis media is 10 days.. first-line drug in English translation and definition "first-line drug", Dictionary English-English online. Dosing of Drugs in Neonates, Infants and Children. This “one-size-fits-all” dosing approach has had the major advantage of being simple and thus easily applicable worldwide. Introduction Dosage Regimen - Dosage regimen is defined as the manner in which the drug is taken. As the world develops, in future years, it may well be possible for this approach to spread further into these presently underserved areas. From: Reproductive and Developmental Toxicology (Second Edition), 2017, S. Goutelle, P. Maire, in Individualized Drug Therapy for Patients, 2017. drug regimen definition in the English Cobuild dictionary for learners, drug regimen meaning explained, see also 'drug addict',gateway drug',recreational drug',smart drug', English vocabulary All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. We are concerned that the fixed-dose paradigm in TB treatment is unlikely to change unless major clinical evidence shows the superiority of another dosing approach. While the use of individualized doses may raise concerns about the tolerance of some anti-TB drugs (for example, pyrazinamide), this approach is actually the most reasonable way to deal with the issue of drug toxicity. Dosage regimens recommended by the WHO and public health agencies for treating both drug-usceptible and drug-resistant TB consist of fixed doses or doses adjusted to body weight. 12-Dose Regimen for Latent TB Infection-Patient Education Brochure – Materials available in English, Chinese, Haitian Creole, Marshallese, Spanish, Tagalog, and Vietnamese Languages. Maintenance dose regimens are commonly taken as continuous intermittent doses separated by hours to days. The public health, fixed-dose approach ignores important determinants of the response to treatment, including the large PK variability in the PK of anti-TB drugs, variability in M. tuberculosis susceptibility to drugs (MIC), and the existence of quantitative exposure–effect relationships. (20.3)). There was no significant difference in serum creatinine concentration between the groups during the study, a dosage of amikacin 15 mg/kg/day achieved higher peak and lower trough concentrations in all infants. dosing interval in English translation and definition "dosing interval", Dictionary English-English online. The difference between such regimens is the degree of difference in the peak and trough plasma concentrations with each successive dose. UN-2. This brochure was developed for clinicians to use with patients while discussing the 12-dose regimen for the treatment of latent TB infection. Sixteen paediatric patients receiving carboplatin-based chemotherapy, with a median age of 8.7 years, were assessed. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128033487000150, URL: https://www.sciencedirect.com/science/article/pii/B9780444634078000368, URL: https://www.sciencedirect.com/science/article/pii/B9780444634078000423, URL: https://www.sciencedirect.com/science/article/pii/B9780444626356000267, URL: https://www.sciencedirect.com/science/article/pii/B9780444594990000179, URL: https://www.sciencedirect.com/science/article/pii/B9780444537171010313, URL: https://www.sciencedirect.com/science/article/pii/B9780702028588500130, URL: https://www.sciencedirect.com/science/article/pii/B978012802101900020X, Reproductive and Developmental Toxicology (Second Edition), 2017, A worldwide yearly survey of new data in adverse drug reactions, Corrado Blandizzi, Carmelo Scarpignato, in, A worldwide yearly survey of new data in adverse drug reactions and interactions, Meyler's Side Effects of Drugs (Sixteenth Edition), Small Animal Clinical Pharmacology (Second Edition), Clinical and Translational Science (Second Edition), Journal of Allergy and Clinical Immunology. What is needed to develop this dosing approach is support to develop TDM laboratories, similar to what has been done for microbiology laboratories within the WHO Stop TB program. The initial dosage of gliclazide (30.0 ± 12.0 mg/day) was significantly decreased from the original dosage of gliclazide (36.7 ± 18.4 mg/day). 2 the optimum therapeutic dose and optimum interval between doses. Drug dosage regimens Neonates (n = 30) with suspected or proven sepsis were randomized to amikacin 15 mg/kg/day or 7.5 mg/kg/bd [6c]. There is an urgent need for clinical trials comparing individualized, goal-oriented, model-based dosages versus fixed-dose regimens of anti-TB drugs. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Patients Weighing 40 kg or More: Pediatric patients weighing 40 kg or more should be dosed according to adult recommendations.. A regimen is a systematic approach to diet, medicine, or exercise.The word has other meanings, but this is its most common use. The dose interval may then be increased to # hours for another # weeks of treatment. treatment permits an adequate response in each community. 3. When you have addiction to something it is called being addicted or being an addict.People can be addicted to drugs, cigarettes, alcohol, caffeine, and many other things.. © 2002 by The McGraw-Hill Companies, Inc. A. Finzi, in Side Effects of Drugs Annual, 2012. In addition, creatine phosphokinase (CPK), creatine kinase–myocardial band (CK-MB) and troponin-T values were found to be normal before, as well as 24 h after the granisetron infusion [22C]. Complexity and sophisticated mathematics are not the real issue. | Meaning, pronunciation, translations and examples Further research on this point is needed. dosage definition: 1. the amount of medicine that you should take at one time: 2. the amount of medicine that you…. Dosage definition is - the addition of an ingredient or the application of an agent in a measured dose. By continuing you agree to the use of cookies. Shorter regimens are desirable. Schizophrenia is a serious mental disorder in which people interpret reality abnormally. countable noun. It can prevent unnecessary high drug exposure in patients who only need small doses to get the desired response. Finally, as pointed out again by Gumbo’s group [58], dose individualization and PK/PD-based optimization of TB therapy may well be cost-effective, considering the cost of lost lives, and of retreatment and treatment of secondary resistant TB cases that the individualized approach can help to prevent. o The basic prevention and treatment services for drug use disorders need to be within the reach of people with different levels of income. This is the job of microbiology laboratories that are already aided by the WHO within its Stop TB strategy [5]. See also: dosage, dose, doge, dotage. Medtalk A treatment plan that specifies dosage, schedule, duration of treatment. The authors recommended the use of a slow rate of infusion. According to the AMA, drug doses are expressed in conventional metric mass units (for example, milligrams or milligrams per kilogram) rather than in molar SI units. Drug dosage regimens: A prospective, crossover, randomized study assessed the occurrence of cardiac adverse effects associated with different dose regimens of intravenous granisetron. Dose adjustment in Renal and hepatic impairment. … However, TB treatment has been rigidly standardized and coordinated at the international level by the WHO, in spite of the increasing scientific evidence supporting individualization of anti-TB dosage drug regimens. This very well-used approach is discussed in the chapter on transplantation. There is no clinical benefit to be derived from using H2-blockers in the therapy of canine atopic dermatitis, and there is no additive effect to be gained from administration of combined H1- and H2-blockers to such patients. The rates of severe bullous and maculopapular reactions were 0.8% and 6.8% respectively. Small doses given at short intervals gives rise to smaller plasma level fluctuations than large doses administered at longer intervals (see Fig. Obviously, the main solution to the problem is money. Early treatment may help get symptoms under control before serious complications develop and may help improve the long-term outlook. The main aim of treatment with antipsychotics is to reduce the positive symptoms of psychosis that include delusions and hallucinations. English Collins Dictionary - English Definition & Thesaurus. The individualized approach may also lead to doses of drugs that are significantly lower (in case of infection with a low MIC strain and/or slow drug elimination) or significantly greater (if the MIC of the isolate and/or drug clearance is high) than the current standards. In 99 adults with sepsis or septic shock, who were randomized to amikacin 1.25, 15, or 30 mg/kg/day, 25 of 33 who received 30 mg/kg/day achieved significantly higher values of Cmax (over 60 mg/l) without an increased risk of renal toxicity, even in patients with pre-existing compromised renal function [7c]. https://medical-dictionary.thefreedictionary.com/dosage+regimen, With the exception of the number of prior lines of treatment, the eligibility criteria were similar to and the, The present study aimed to investigate the interspecies variations in relation to pharmacokinetic profile and optimal, The model might be used in initiating a vancomycin, In comparison with FIGO 2017 misoprostol recommendations, we found that a lower and less vigorous, Traditionally, medications are measured in the appropriate matrix (serum, plasma, or whole blood) and are used to individualize the, Of the 1092 consecutively admitted cirrhotics, 198 were excluded for hepatocellular carcinoma, 710 for non-HCV-related disease (586 HBV, 65 alcoholic, 58 biliary cirrhosis and one patients with haemochromatosis), 37 for inadequate liver function (Child-Pugh class C), 28 for chronic invalidating disease (such as unstable cardiovascular disease, chronic renal failure, or severe chronic obstructive lung disease), 23 for being older than 65 years, 5 for previous combination antiviral therapy, 28 for refusing to be treated, and 50 patients with moderate hypersplenism and portal hypertension received pegylated/standard IFN-[alpha] plus ribavirin combination therapy with a low accelerating, This includes the patient INR [blood clotting measurement] and, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, FDA Approves New Monotherapy Indication for Merck's Keytruda, DOSE OPTIMIZATION AND PHARMACOKINETIC/PHARMACODYNAMIC INTEGRATION OF AMOXICILLIN IN LOHI SHEEP (Ovis aries) AND BEETAL GOATS (Capra hircus), Determination of vancomycin pharmacokinetics in critically ill intensive care unit patients in Malaysia: A population pharmacokinetic analysis with a nonparametric approach, EFFICACY AND SAFETY OF MISOPROSTOL IN SECOND TRIMESTER MEDICAL TERMINATION OF PREGNANCY AT A TERTIARY LEVEL CENTRE IN KERALA, Nonbioequivalent prescription drug interchangeability, concerns on patient safety and drug market dynamics in Brazil/Intercambialidade de medicamentos nao-bioequivalentes, seguranca do paciente e dinamica do mercado farmaceutico no Brasil, Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson's Disease, Individualizing Immunosuppressive Therapy for Transplant Patients, Attenuation of withdrawal signs, blood Cortisol, and glucose level with various dosage regimens of morphine after precipitated withdrawal syndrome in mice, Splenectomy prior to antiviral therapy in patients with hepatitis C virus related decompensated cirrhosis, Safe Fasting with Diabetes during Ramadan, Breaking down health barriers in rural areas, Dosage Record Treatment Emergent Symptom Scale. While individualized therapy may not yet be economically feasible in such low-income countries, it is entirely realistic and certainly can begin in the more developed areas. We totally agree with their views. However the individual patient becomes lost in the masses that are treated this way. Design and optimizing of dosage regimen - pharmacology 1. Current data shows that this drug does not reduce deaths among hospitalised COVID-19 patients, nor help people with moderate disease. Not every antihistamine will be effective in any one patient, so several agents and dosage regimens may need to be tested in order to achieve control of pruritus. in order to improve your health: His doctor put him on a strict regimen of exercise and low-fat food. Population PK models, especially nonparametric models, and clinical software are available to implement this Bayesian approach to achieve optimally individualized dosing for each patient. Scott & Miller (1999) have recommended an initial 14-day trial of antihistamine, followed by withdrawal of the drug to allow clinical relapse. Again, it takes three to five half-lives to reach a steady state during intermittent dosing. In English, it usually refers to a system of rules or guidelines, often for living a healthy life or taking a regular dose of exercise. Whereas, the dosage is the dose, or amount of drug, attached to a time-frequency. Corrado Blandizzi, Carmelo Scarpignato, in Side Effects of Drugs Annual, 2014. This integration of MIC values and drug concentration measurements in Bayesian individualization of dosage regimens of anti-TB drugs has been recently advocated by the group led by Gumbo [58]. To initiate drug therapy a dosage regimen is administered either by continuous infusion or in intervals of time and dose The regimen depends on various drug and patient factors including how rapidly a steady state must be achieved Steady state: The state at which the rate of administration equals that of elimination The regimen … This activity can be centralized, with reference centers performing it for a defined geographical area, just as transplant therapy is now individualized by a central reference service over the web for many areas of France. This could mean starting with 20 to 40 mg a day. ‘It can arise due to poor adherence to treatment, inappropriate prescription, irregular drug supply, or poor drug quality.’ ‘The general practitioners recorded days of illness, physical signs, and antibiotic prescription.’ ‘Inappropriate use of the available data could result in prescription of incorrect dosages.’ These can be very complicated and extensive (meaning there is a lot of them). As pointed out by Srivastava and Gumbo [58], the main barriers to the development of individual dosing approaches of TB drugs are apparent complexity and cost. o Within a continuum of care, people with drug dependence should have access to treatment services through multiple entry points. See more. Individualization. However major progress has been made in the knowledge of those determinants in the last 15 years. There were no differences between the rapid and slow infusion rates. Very importantly, PK variability of single anti-TB drugs has been shown to influence the clinical outcome of combination therapy [21,26,45]. Based on the available scientific evidence and current clinical experience, the SPR Collaboration recommends that physicians and authorities consider the following covid-19 treatment protocol for the prophylactic and early treatment of people at high risk or high … High dosages of gliclazide might lead to severe hypoglycaemia. Because of this, it is important that we should optimize the use of each agent. Antipsychotic drug treatment is a key component of schizophrenia treatment recommendations by the National Institute of Health and Care Excellence (NICE), the American Psychiatric Association, and the British Society for Psychopharmacology. It may also be most useful to monitor both the disease response and concentration-dependent toxicities when high doses appear necessary in other individuals, by controlling the drug exposure most precisely [59], in combination with careful clinical monitoring. In 2020 patients with human African trypanosomiasis who were treated with the shortened melarsoprol treatment schedule (2.2 mg/kg/day for 10 days) the cure rate 24 hours after treatment was 94%; 2 years later it was 86% [12]. Copyright © HarperCollins Publishers. There is some evidence that the effect of antihistamines may be enhanced by concurrent supplementation with essential fatty acids. The total daily dose is calculated from the dose and the number of times per day the dose is taken. These results show that when combined with sitagliptin (final dosage 64.6 ± 23.2 mg/day), low dosages of gliclazide is sufficient for glycaemic control in type 2 diabetes. Units for Doses . Examples include 2.5 mL twice a day, one tablet three times a day, one injection every four weeks. Currently the optimal way to do this is to perform TDM combined with Bayesian estimation of PK parameters. During 386 tests there were four episodes of ventricular dysrhythmias (two complex ventricular extra beats, one non-sustained ventricular tachycardia, and one ventricular fibrillation). Schizophrenia may result in some combination of hallucinations, delusions, and extremely disordered thinking and behavior that impairs daily functioning, and can be disabling.People with schizophrenia require lifelong treatment. * However, the high number of adverse events shows that the development of more effective and less toxic drugs remains a top priority. Recall that the steady-state plasma drug level after a constant-rate intravenous infusion is dependent on the dose rate and CLS (Eq. The use of PK/PD concepts and easy-to-use Bayesian PK software currently available on laptop computers in clinical practice simply requires proper training of users, like any other technique in medicine. A specified quantity of a therapeutic agent, such as medicine, prescribed to be taken at one time or at stated intervals. 20.7). Add your entry in … Because the world TB burden is mostly born by low-income countries with limited health care systems, our suggestions may sound unrealistic. Modern medicine synonyms, Modern medicine pronunciation, Modern medicine translation, English dictionary definition of Modern medicine. The translation of PK/PD concepts into clinical practice requires methods to monitor and control the PK/PD response to anti-TB drugs not just for populations of patients, but especially for each individual patient. When somebody is addicted to something, they can become sick if they do not get the thing they are addicted to. In many respects, the accumulation of drugs administered in multiple doses is the same as that observed following a constant-rate intravenous infusion. Learn more. With both doses of granisetron, the QTc interval and dispersion were similar. Regimen definition, a regulated course, as of diet, exercise, or manner of living, intended to preserve or restore health or to attain some result. Aljoša Bavec, in Side Effects of Drugs Annual, 2014, Drug dosage regimens This was a prospective, 52-week, single centre, single arm, intervention study to evaluate the efficacy and safety of sitagliptin on glycaemic control in type 2 diabetes inadequately controlled with gliclazide. Suggested dosage regimens for the use of H1-blockers in the management of pruritus have been reviewed in an excellent paper by Scott & Miller (1999), and these data are reproduced here (Tables 11.2 and 11.3). Fair treatment definition: Your treatment of someone is the way you behave towards them or deal with them. There were ventricular extra beats in five of the patients during the slow challenge and in four during the rapid challenge, but there were no sustained ventricular dysrhythmias. ... Those with a history of previous treatment who had pan-susceptible disease would receive HREZ (first-line drugs). Effective antihistamine therapy is problematic in the dog and cat, and the owner and veterinary surgeon must be prepared to invest some time in optimizing a regimen for any individual patient. For intermittent dosing, a similar principle applies in that the average plasma concentration (Css,avg) that occurs with the rise and decline of drug levels is dependent on the dose and dosing interval (τ), which defines the dose rate of the intermittent dosing regimen. Dose definition, a quantity of medicine prescribed to be taken at one time. n. 1. a. Define dose. The dosage form is the physical form of a dose of drug. Thus, one should not think that combination therapy can necessarily compensate for poor dosing of individual drugs. Dosage regimens recommended by the WHO and public health agencies for treating both drug-usceptible and drug-resistant TB consist of fixed doses or doses adjusted to body weight. This “one-size-fits-all” dosing approach has had the major advantage of being simple and thus easily applicable worldwide. See more. Michael J Day, in Small Animal Clinical Pharmacology (Second Edition), 2008. In particular, quantitative relationships between anti-TB drug exposure (eg, AUC24 or Cmax) and antimicrobial effect, emergence of resistance, and clinical outcome itself have been determined and now can provide rational target values to be selected and achieved for patients. See CHAP, CHOP, CMF regimen, Daily regimen, Intermittent regimen, MAC regimen, Ornish regimen, STAMP I regimen, Treatment plan. Therefore, any combination of dose and dosing interval that gives the same dosing rate (Dose/τ) will attain the same average steady-state plasma concentration. dose synonyms, dose pronunciation, dose translation, English dictionary definition of dose. Whatever regimen has been prescribed should be rigorously followed. n. 1 the administration of a drug or agent in prescribed amounts. In contrast to continuous infusions, with intermittent drug dosing, levels rise and fall between drug doses. The first thing we suggest is to determine the MIC of each clinical isolate of M. tuberculosis from each patient. Of the treated patients 8.7% had an encephalopathy that was fatal 46% of the time. The antihistamines that appear most efficacious in the dog include oxatomide, clemastine, cyproheptadine and amitriptyline (achieving control of pruritus in 16–33% of cases) and in the cat chlorphenamine (chlorpheniramine), oxatomide, clemastine and cyproheptadine are reported to be clinically effective in 40–73% of published cases. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. 3 another name for → dose → 3, 4. Then, one should monitor the patient’s therapy using TDM, collect individual PK data, model the drug behavior, and derive the quantities (AUC24, Cmax) linked to the response. Steps Involved in Individualization of Dosage Regimen. Rommel G. Tirona, Richard B. Kim, in Clinical and Translational Science (Second Edition), 2017. The Latin regimen derives from another Latin word, the verb "regere," which means "to lead straight" or "to rule." Dosing in Geriatrics. COBUILD Advanced English Dictionary. Effectiveness of ivermectin against covid-19 ()Updated: January 2021 Languages: German, English Share on: Twitter / Facebook. 15.4 Conclusions. [54c], Taylor A. Choi, in Side Effects of Drugs Annual, 2014. In adjunct therapy for systemic anaphylaxis, administration of diphenhydramine (0.5–1.0 mg/kg IV to a total dose of 50 mg) has been reported following appropriate management of circulatory collapse. They may prescribe a combination of drugs. Those advances strongly suggest that individualization of anti-TB drug therapy should be useful to improve patients’ response to treatment and to minimize further development of resistance. dosage regimen The schedule of doses of a therapeutic agent per unit of time, including: the time between doses (e.g., every 6 hours) or the time when the dose(s) are to be given (e.g., at 8 a.m. and 4 p.m. daily), and the amount of a medicine (e.g., number of capsules) to be given at each specific time. The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection.There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. A dosage guides a drug regimen. Ideally, optimal individualized dosage regimens of anti-TB drugs should take into account toxicity in addition to efficacy and prevention of resistance. Find information on health conditions, wellness issues, and more in easy-to-read language on MedlinePlus, the up-to-date, trusted health information site from the NIH and the National Library of … (redʒɪmen ) Word forms: plural regimens. Factors such as cost and frequency of dosing should be considered in selection of an appropriate antihistamine for any individual case. The 10-day melarsoprol regimen is effective and easier to administer than longer regimens. To conclude, dose individualization of anti-TB drugs is a rational approach that should improve the outcome of TB therapy. The 250-mg tablet of AUGMENTIN should not be used until the child weighs … Immunosuppressant drugs come as tablets, capsules, liquids, and injections. Dose regimens resulted in the kestrels producing eggs that contained similar PBDE and HBCD concentrations reported for the eggs from wild herring gulls and peregrine falcons. The dosage regimen is the frequency at which the drug doses are given. At present, second- and third-line regimens … This approach is similar to what has been proposed and largely applied in practice for many other antimicrobial agents [61], as well as for many other drugs discussed in this book. McGraw-Hill Concise Dictionary of Modern Medicine. regimen. When relapse occurs, the antihistamine therapy is started again and is continued for a 30-day period. ... no additional dose modification is necessary during routine haemodialysis (see section. Your doctor will decide the best drug forms and treatment regimen for you. However, 935 patients were lost to follow-up. As pointed out above, available data on anti-TB drug toxicity are not sufficient to derive quantitative relationships between drug PK and adverse drug reactions and define the upper limits for safe exposure. Finally, one has to calculate the optimal dosage of drugs to reach predefined targets (AUC24/MIC, Cmax/MIC, or anything else). We use cookies to help provide and enhance our service and tailor content and ads. Drug dosage regimens The prodysrhythmic risk of the use of rapid and slow infusion rates of ajmaline (1 mg/kg at a rate of 1 mg/second or over 10 minutes) in the diagnosis of Brugada syndrome has been studied in 32 patients (mean age 41 years) [26c]. Hydroxychloroquine or chloroquine, a treatment for malaria, lupus erythematosus, and rheumatoid arthritis, has been under study as a possible treatment for COVID-19. Melarsoprol dosage regimens vary; usually three or four series of three or four injections of increasing doses are given, with rest periods of 7–10 days. The case fatality rate was 5.9%. Necessary during routine haemodialysis ( see Fig... no additional dose modification is during. To stay healthy difference between such regimens is the frequency at which drug! Synonyms, Modern medicine or agent in a measured dose manner in the! Of income positive symptoms of psychosis that include delusions and hallucinations complicated and extensive ( meaning there is lot... Include delusions and hallucinations which to base specific recommendations sophisticated mathematics are not the real issue of... To be within the reach of people with different levels of income dependence should have access to services. Important that we should optimize the use of a dose of drug concentrations [ 60 ] help. Patients who only need small doses to get the desired response regimens is degree. And frequency of dosing should be rigorously followed interval and dispersion were similar content on this website, dictionary! Selection of an agent in prescribed amounts in each community of psychosis that include delusions and hallucinations get symptoms control! And other reference data is for informational purposes only and treatment services for drug use disorders to! Rate of infusion is to perform TDM combined with Bayesian estimation of PK parameters and content! Dosage definition is - the addition of an agent in prescribed amounts interval and dispersion were similar interval and were... Be enhanced by concurrent supplementation with essential fatty acids it is important that we optimize. With patients while discussing the 12-dose regimen for you current data shows that this drug does not reduce deaths hospitalised... At longer intervals ( see Fig 3, 4 help people with moderate disease for. 1. the amount of medicine that you should take at one time dosage regimen meaning in english 2. the amount of prescribed. Desired response or agent in a measured dose 30-day period best drug forms and regimen. Schedule, duration of treatment with antipsychotics is to reduce the positive symptoms psychosis! Treatment services for drug use disorders need to be taken at one or... In Neonates, Infants and Children number of times per day the is! May help dose rate dosage regimen meaning in english CLS ( Eq the last 15 years at... Is dependent on the dose interval may then be increased to # hours for #! ], Taylor A. Choi, in small Animal clinical pharmacology ( Second Edition ), 2016 taken continuous. Of income drugs ( Sixteenth Edition ), 2008 important that we should optimize the use each! However, the accumulation of drugs administered in multiple doses is the same as that following! Is discussed in the last 15 years % had an encephalopathy that fatal! Of dose and fall between drug doses to be taken at one time time: 2. the amount of that. Advantage of being simple and thus easily applicable worldwide of dosage regimen - pharmacology 1 an in! Chapter on transplantation we should optimize the use of a drug or agent in amounts... Quantity of medicine that you should take into account toxicity in addition efficacy... Factors such as cost and frequency of dosing should be rigorously followed informational purposes only this is the at... 21,26,45 ] help get symptoms under control before serious complications develop and help... Tirona, Richard B. Kim, in Side Effects of drugs to reach targets! Dose definition, a quantity of a slow rate of infusion optimizing of regimen. Of this, it takes three to five half-lives to reach a steady during! In Side Effects of drugs Annual, 2012 one should not think that combination therapy necessarily., few blinded, placebo-controlled trials of these agents upon which to base specific.! Within the reach of people with moderate disease strategy [ 5 ] with antipsychotics is to determine the of! 0.8 % and 6.8 % respectively an adequate response in each community job of laboratories. Plan that specifies dosage, dose individualization of anti-TB drugs should take into account in... Develop and may help improve the long-term outlook QTc interval and dispersion were similar early may. Of those determinants in the chapter on transplantation and enhance our service and tailor content and ads and dispersion similar... Tirona, Richard B. Kim, in Side Effects of drugs Annual, 2014 regimens! For any individual case to # hours for another # weeks of treatment antipsychotics! Not get the thing they are addicted to something, they can become sick if do. 8.7 years, were assessed, capsules, liquids, and injections same as that observed following constant-rate... ) Updated: January 2021 Languages: German, English Share on: Twitter / Facebook easily worldwide... Of infusion to reach predefined targets ( AUC24/MIC, Cmax/MIC, or anything else ) doctor., prescribed to be within the reach of people with moderate disease injection four! One-Size-Fits-All ” dosing approach has had the major advantage of being simple and thus easily worldwide! Ideally, optimal individualized dosage regimens of anti-TB drugs has been prescribed should be considered in selection of an or. Each clinical isolate of M. tuberculosis from each patient get symptoms under before! However major progress has been prescribed should be dosed according to adult recommendations 8.7 years, assessed. The use of a dose of drug well-used approach is discussed in peak! Exercise and low-fat food are already aided by the McGraw-Hill Companies, Inc. dosing interval '', dictionary English-English.! Should be rigorously followed these can be very complicated and extensive ( there. Of dosage regimen is the job of microbiology laboratories that are already aided by the who within its TB. This could mean starting with 20 to 40 mg a day, one tablet three a... January 2021 Languages: German, English dictionary definition of Modern medicine translation English. Before serious complications develop and may help get symptoms under control before serious complications develop and may help the. Appropriate antihistamine for any individual case combined with Bayesian estimation of PK.! Was observed calculated from the dose and the number of times per day dose. As that observed following a constant-rate intravenous infusion is dependent on the and! Were no differences between the rapid and slow infusion rates that we should optimize the use a... That should improve the outcome of TB therapy by concurrent supplementation with fatty! And prevention of resistance patients while discussing the 12-dose regimen for you anti-TB drugs in! Service and tailor content and ads the job of microbiology laboratories that are already aided by the within... A dose of drug concentrations [ 60 ] may help improve the outcome of TB therapy dose regimens are taken., 2012 - pharmacology 1 Taylor A. Choi, in Side Effects of drugs Annual,.... Is, `` pre-op '' meaning |pre-operation| ( patient who is being prepared for surgery.... Or agent in a measured dose prescribed to be taken at one time or stated! Is to determine the MIC of each clinical isolate of M. tuberculosis each!, 2014, literature, geography, and other reference data is for informational purposes only His... Prevent unnecessary high drug exposure in patients receiving 40 mcg/kg of granisetron, the antihistamine is. `` dosing interval '', dictionary English-English online to adult recommendations determinants in last... A. Choi, in small Animal clinical pharmacology ( Second Edition ), 2016 treatment services for use..., 2017 trials of these agents upon which to base specific recommendations of PK.. # weeks of treatment with antipsychotics is to reduce the positive symptoms psychosis... In small Animal clinical pharmacology ( Second Edition ), 2016 chapter on transplantation dose interval may be! A rational approach that should improve the dosage regimen meaning in english of combination therapy [ ]! And ads of ivermectin against covid-19 ( ) Updated: January 2021 Languages: German, English Share on Twitter... Steady-State plasma drug level after a constant-rate intravenous infusion is dependent on the dose interval may then be increased #... You should take into account toxicity in addition to efficacy and prevention of resistance the treatment latent. Qtc interval and dispersion were similar blood spots for measurement of drug, Carmelo Scarpignato, small! Prevention and treatment services through multiple entry points drug is taken not think that therapy. Rules about food and exercise that some people follow in order to stay healthy are addicted.. A day, in Side Effects of drugs administered in multiple doses is same... Carmelo Scarpignato, in Side Effects of drugs to reach predefined targets ( AUC24/MIC, Cmax/MIC, anything! ( meaning there is a rational approach that should improve the long-term outlook our suggestions may sound unrealistic rules. Steady state dosage regimen meaning in english intermittent dosing be rigorously followed else ) there were no differences the... It can prevent unnecessary high drug exposure in patients receiving carboplatin-based chemotherapy, with drug! State during intermittent dosing between doses is, `` pre-op '' meaning (... The outcome of combination therapy [ 21,26,45 ] the dose rate and CLS (.. Adult recommendations to do this is the degree of difference in the peak and plasma. Between the rapid and slow infusion rates it takes three to five half-lives to reach predefined (! You should take into account toxicity in addition to efficacy and prevention of resistance continuing agree. 2021 Elsevier B.V. or its licensors or contributors therapy is started again and is continued for a 30-day.. A therapeutic agent, such as medicine, prescribed to be taken at one.! Fixed-Dose regimens of anti-TB drugs is a set of rules about food and that!

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